A plaque remaining from the Big Apple Night Club at West 135th Street and Seventh Avenue in Harlem.

Above, a 1934 plaque from the Big Apple Night Club at West 135th Street and Seventh Avenue in Harlem. Discarded as trash in 2006.

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Entry from May 25, 2017
“I’ve studied Basic Human Anatomy so much that I know it like the back of my hand”

To “know something like the back of one’s hand” is to know it very well. A student joke applies this expression to a human anatomy test.

“Going to Anatomy. I know this like the back of my hand. Easy A here I come!” was posted on Twitter on August 29, 2008. “I’ve studied Basic Human Anatomy so much that I know it like the back of my hand” was posted on Reddit—Jokes on May 26, 2017.


Wiktionary: know like the back of one’s hand
Verb
know (something) like the back of one’s hand

1. (transitive, idiomatic) To be intimately knowledgeable about something, especially a place.

Twitter
Jennifer Beese‏
@bottlethecrazy
Going to Anatomy. I know this like the back of my hand. Easy A here I come!
7:26 AM - 28 Aug 2008

Twitter
Q.‏
@thedancindoll
the spine is divided into 3 parts- cervical, thorasic and lumbar. @ericallanjr (u know I know anatomy like the back of my hand.)
12:44 PM - 25 Sep 2009

Twitter
Alfonso Noad‏
@fonzo54
Feeling pretty good. Just studied my anatomy lab stuff and seem to kno it like the back of my hand. Both real pics and book diagrams
8:12 PM - 31 Jan 2010

Twitter
Patience‏
@_patiencee_
anatomy tests suck. :( staying up to study ‘til i know this stuff like the back of my hand.
10:23 PM - 12 Jan 2011

Twitter
B A L E I G H‏
@begrace_ful
done studying for anatomy...i know it like the back of my hand...imma ace this test. #studied #prepared #ohitfeelsgoodtobepreparedforatest
11:36 PM - 19 Sep 2011 from Demopolis, AL

Twitter
Sara Pavich‏
@SayPavich
“I need to know anatomy like the back of my hand. Except we haven’t done limbs yet so I’ll say like the inside of my thorax.” -Meghan Melina
8:45 PM - 6 Feb 2012

Twitter
Simone’ Josephe’ ♈️‏
@_bitterSWEETme
My summer goal is to know this anatomy and physiology book like the back of my hand before the fall comes around ! 🤓
12:03 PM - 11 May 2017

Reddit—Jokes
I’ve studied Basic Human Anatomy so much
submitted May 26, 2017 by abandonvp
I know it like the back of my hand.

Posted by Barry Popik
New York CityEducation/Schools • Thursday, May 25, 2017 • Permalink