“Just Say No (to drugs)” was a public service advertising campaign in the 1980s and 1990s. There have been many jokes about “talking to drugs.” “They said ‘Say no to drugs,’ so I did, but it didn’t have any effect on my aspirin. Strange, really. First they say it’s good to talk to plants, now they want you to talk to drugs. Didja ever notice that if you talk to drugs, people assume you’re on them?” was posted on the newsgroup Google Groups: rec.humor on May 12, 1994.
 
“People who ‘just say no to drugs’ are typically the ones I search for narcotics. Why? THEY TALK TO DRUGS” was posted on Twitter by The Night Stalker on July 22, 2009. “Say no to drugs… but then again if your talking to drugs you probably are on drugs” was posted on Twitter by Ryan k. Brown on February 28, 2011. “The saying, ‘Say no to drugs’ has always made me laugh. If you’re talking to drugs, it’s probably too late to say no to them” was posted on Twitter by John H. Nelson Jr. on May 27, 2014.
   
   
Wikipedia: Just Say No
“Just Say No” was an advertising campaign, part of the U.S. “War on Drugs”, prevalent during the 1980s and early 1990s, to discourage children from engaging in illegal recreational drug use by offering various ways of saying no. The slogan was created and championed by First Lady Nancy Reagan during her husband’s presidency.
       
Google Groups: rec.humor
Joke
Kristina Lindberg
5/12/94
They said “Say no to drugs,” so I did, but it didn’t have any effect on my aspirin. Strange, really. First they say it’s good to talk to plants, now they want you to talk to drugs. Didja ever notice that if you talk to drugs, people assume you’re on them?
   
Twitter
The Night Stalker
@kolchak
People who “just say no to drugs” are typically the ones I search for narcotics. Why? THEY TALK TO DRUGS.
10:18 PM - 22 Jul 2009
     
Twitter   
Ryan k. Brown
@rysoccer
Say no to drugs… but then again if your talking to drugs you probably are on drugs
1:47 PM - 28 Feb 2011
   
Twitter
Raphael 武道家
@BlueWaterDojo
Say no to drugs! ...But then again if you are talking to drugs you may already be on drugs!
3:54 PM - 4 Mar 2011
 
Twitter 
Osiris The Father
@iwearpeachpants
Say no to drugs…but then again if u talk to drugs ur probably already on them
8:49 PM - 2 Mar 2011 from Euclid, OH
 
Twitter
you are beautiful.
@theconvotweet
Teacher: Say no to drugs!
Student: So you want me to talk to drugs? #theconvotweet
1:18 PM - 11 Aug 2011
   
Twitter
David Rhodes
@Rhodes411
Say no to drugs!
Then again, if you’re talking to drugs, you’re probably already on drugs.
12:20 PM - 8 Mar 2012
 
23 January 2014, University Wire (Carlsbad, CA), “Mary Jane steals hearts, but not this one” by Jack Gelbe:
It’s incredibly simple: SAY NO TO DRUGS. Then again, if you’re talking to drugs, you’re probably on drugs.
       
Twitter
John H. Nelson Jr.
@Dominus65
The saying, “Say no to drugs” has always made me laugh. If you’re talking to drugs, it’s probably too late to say no to them.
7:22 PM - 27 May 2014
 
Urban Dictionary
Marijuana
Marijuana is the flower off of the cannabis plant. Not a drug, drugs are bad. Leagalize it. (in Canada perferrably)
Marijuana is gods remedy for hatred:
If the whole world smoked a joint at the same time, There would be world peace for atleast two hours. Fowllowed by a global food shortage. Say No to drugs! Then again, if your talking to drugs, you’re probably already on drugs.
#weed#ganja#pot#herb#dank#maryjane#quid#green#reefer
by Tristan For The Win February 03, 2015
 
Google Groups: alt.recovery.aa
Say no to drugs!
Dr Rev MFKing Jr
4/20/17
Say no to drugs!
 
Then again, if you’re talking to drugs, you’re probably already on drugs.
   
Reddit—Jokes
Posted by u/blueeyedbanditjr February 22, 2019
The saying “say no to drugs” has always made me laugh.
If you’re talking to drugs, it’s probably too late to say no to them.
   
Reddit—Showerthoughts
Posted by u/invertedparadoxxx February 22, 2019
The saying “SAY NO TO DRUGS” always sounded funny.
If you’re talking to drugs then it’s probably too late to say no to them at this point.
 
LaffGaff
By laffgaff February 25, 2019
Say No To Drugs Joke
The saying, “Say no to drugs” has always made me laugh.
If you’re talking to drugs, it’s probably too late to say no to them.