“The only time it’s good to yell ‘I have diarrhea’ is when you’re playing Scrabble because it’s worth a shitload of points” is a jocular saying that has been printed on several images. Greek-American comedian, actor and writer Zach Galifianakis said on his comedy album Live at the Purple Onion (2007):
 
“The only good time to say I have diarrhea is during a game of Scrabble, because it’s worth a shitload of points.”
 
Zach Galifianakis hosted the late night television show Saturday Night Live on March 13, 2011, when he repeated the Scrabble joke:
 
“The only good time to yell out, ‘I have diarrhea,’ is when you’re playing Scrabble.”
   
         
Wikipedia: Scrabble
Scrabble is a word game in which two to four players score points by placing tiles bearing a single letter onto a board divided into a 15×15 grid of squares. The tiles must form words that, in crossword fashion, read left to right in rows or downward in columns, and be included in a standard dictionary or lexicon.
           
Wikiquote: Zach Galifianakis
Zachary Knight “Zach” Galifianakis (born October 1, 1969) is a Greek-American comedian, actor and writer.
(...)
Live at the Purple Onion (2007)
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The only good time to say I have diarrhea is during a game of Scrabble, because it’s worth a shitload of points.
 
Twitter
Brian Smith
@HomelessBrian
I don’t mean to be gross, but the only time it’s good to yell “I have diarrhea” is when you’re playing Scrabble because it’s worth a shitloa
9:40 AM - 11 Jul 2007
 
14 July 2007, The Gazette (Montreal, Quebec), “Zach Galifianakis won’t be kicking any more empty seats at this twisted show” by Bill Brownstein, pg. E3:
Hilarious yet clearly deranged. Still not convinced on either count? Then chew on this chestnut: “The only time it’s cool to yell: ‘I have diarrhea!’ is when you’re playing Scrabble.”
     
Google Books
Mock Stars:
Indie Comedy and the Dangerously Funny
By John Wenzel
Golden, CO: Speck Press
2008
Pg. 168:
“I hate to be gross, but the only time it’s good to yell out ‘I have diarrhea’ is when you’re playing Scrabble — because it’s worth a shitload of points.”
 
Twitter
Matt Shiv
@shivvy
Replying to @BigSamThompson
@bigsamthompson The only time it’s good to yell “I have diarrhea” is when you’re playing Scrabble because it’s worth a shitload of points.
10:25 PM - 17 Nov 2008
 
Reddit—Funny
When is the only time it’s okay to yell “I have diarrhea!”? (self.funny)
submitted September 1, 2010 by IP_Freely
when you’re playing Scrabble
       
Google Groups: alt.tv.snl
Did “SNL” let Zach down?
TMC
3/14/11
http://www.avclub.com/articles/zach-galifianakisjessie-j,53005/
by David Sims March 13, 2011 Saturday Night Live
“Zach Galifianakis/Jessie J”
season 36 , episode 17
(...)
•“The only good time to yell out, ‘I have diarrhea,’ is when you’re playing Scrabble.”
 
Reddit—Funny
“The only good time to say “I have diarrhea” is during a game of Scrabble…” (i.imgur.com)
submitted December 22, 2015 by jeihkeih
   
Reddit—Shower Thoughts
The only time it’s good to yell “I have diarrhea” is when you’re playing Scrabble, because it is worth a crapload of points
submitted March 14, 2017 by RakoGumi
 
Reddit—Oneliners
The only good time to yell “I have diarrhea” is when you are playing scrabble because it is worth a shitload of points.
submitted September 11, 2018 by ronvonjones1